sickle cell clinic and research ,burla,sambalpur,orissa,india

Name :Dr. Dilip Kumar Patel.
Date Of Birth :25^th Dec 1959
Address :3R/27, Doctors’ Colony, Burla, Dist. Sambalpur-768017, Orissa, India.
Telephone :(0663) 2430273, M-9437062273
Educational Qualification:MD (Gen. Medicine)
Designation:Assistant Professor, Dept. of Medicine, V.S.S. Medical College, Burla, India
Educational Qualification: * MBBS – 1983 – V.S.S. Medical College Burla(Sambalpur University)* M.D – 1988 – Gen. Medicine ,S.C.B. Medical College, Cuttack, Utkal University
E-mail Address:drdilippatel25@gmail.com
Subject of interest: Sickle cell disease,Malaria

Ongoing Research Project:

Title : Study of morbidity pattern in sickle cell disease in Western Orissa and its correlation with fetal hemoglobin concentration and different epistatic factors like malaria.

Sponsoring authority: Department of Biotechnology, Government of India, New Delhi vide letter no. BT/PR5894/12/238/2005 dated 28/03/2005 under the programme support category with priority area being HUMAN GENETICS.

Duration: Three years (from date of sanction 28/03/2005).

Collaborating institutes : The project is a multi centric project undertaken at

1. Veer Surendra Sai Medical College, Burla , Orissa

2. Ispat General Hospital, Rourkela, Orissa

3. Institute of Life Sciences, Bhubaneswar, Orissa

Project Coordinator & Principal Investigator:

Dr. Dilip Kumar Patel, Assistant Professor, Department of Medicine, V.S.S. Medical College, Burla , Orissa, India.

Aims & Objectives :

To find out different clinical spectrum of Sickle Cell Disease in two study populations at Burla and Rourkela centres and compare them.
To estimate fetal hemoglobin concentration and genotype in these patients by studying Xmn polymorphism and correlate this with the severity of clinical manifestations.
To study the incidence and severity of P.falciparum infection on sickle cell disease. Sickle cell trait and compare this with age and sex matched controls without sickle cell hemoglobinopathy.
To have a family study for assessment of Hemoglobinopathy status in different family members and provide counseling.
To follow up these cases at periodic intervals over 3 years and provide simple intervention measures.

Research Publications:

1) R.N. Rath, D. K. Patel, P.K. Das, B. K. Das, A. C. Mishra, R.N. Sahu & G. Mohanty Immunopathological Changes in Kidney in Plasmodium Falciparum Malaria:. Indian Jr. Med. Res. (A) 91, March. 1990 p. 129-132.

2) G. C. Mishra. R. Manjunath. S.C.Mishra, D. K. Patel. Clinico-Pathological and Endoscopic Profile of Dysphagia: Jr. International Medicine Science Academy, Vol. 3 No.2, April. 1990. p. 55-58.

3) G. C. Mishra. D. K. Patel. R. N. Sahu. Autosomal Dominant Polycystic Kidney Disease with Lacunar Infarct: Jr. Asso. Ph. India JAPI, Vo1.39, No.10. p.766-768.

4) D. K. Patel. RS. Panda. Changing Patterns of Enteric Fever.: The Indian Practitioner Septermber, 1993. Vol. XLVI, No.9. p.625-631.

5) R.S. Panda. D. K. Patel. Polyunsaturated phosphatidyl choline (EPL Essentials) in Viral Hepatitis: The Indian Practitioner, 1994, Vol. XLVII No.9, p.751-756.

6) D. K. Patel, R.S.Panda. P. Paul. Plasma Viscosity in Sickle Cell Hemoglobinopathy.: The Indian Practitioner, Jan. 1995, Vol. XLVIII, No.1, p. 25-29.

7) A. K. Sinha. G.C. Mishra. D. K. Patel. Effect of Cigarette Smoking Lipid Profile in the Young.: Jr. Asso. Phy. India (JAPI), 1995, Vol. 43, No.3, p.186-188.

8) P.S. Mohandas, D. K. Patel, G. C. Mishra. Plasma Renin Activity, Plasma Aldosterone Concentration and Urine Sodium Excretion as Prognostic Indicators in Nonazotaemic Cirrhosis of Liver:. The Indian Practitioner, Oct. 1995, Vol XL, No.1 0, p. 887-893.

9) D. K. Patel, R. S. Panda. Prevalence of Hepatitis B. Viral infection in patients of Acute and Chronic Liver Disease in Southern and Western Orissa (A comparative Study): Jr. Asso. Phy. India (JAPI) 1995, Vol. 43, No. 12, p. 11841.

10) J.R.Lath, D. K. Patel. Atypical case of Tuberculosis of Stomach presenting as gastric outlet obstruction: Jr. Asso. Phy. India (JAPI). Vol.44, 1996, No.4, p.286.

11) R. S. Panda & D. K. Patel. Sickle Cell Disease with fever An Observation. Paper Presented at 9th Annual Conference of API, Guwahati: 1996.

12) R. S. Panda, D. K. Patel. Pseudo-Tetany: The Indian Practitioner 1996, Vol. XLIX, No.3, p. 262-264.

13) Panda R. S., D. K. Patel, Rath S. C. Study of Immunological Markers of Hepatitis B Viral Infection in Patients of Sickle Cell Disease in a Rural Medical College of Orissa: The Indian Practitioner, July, 1997, Vo1.50, No.7, p. 583-586.

14) D. K. Patel, M. K. Kar. Sickle cell Disease - A review: 1. Science & Tech. (SUJST) 1999 V 01. XI. Sec A, p. 36 -42.

15) D. K. Patel, Patel S., Kar M. K. Clinical Profile of Plasmodium Falciparum Malaria in a Geographical area of Western Orissa associated with high incidence of sickle cell disease: Proceeding of 87th Session of Indian Science Congress, Pune. 2000. p.36-37

16) D. K. Patel. Panda N. C., R. S. Panda. Study of Vaso-occlusive crisis in sickle cell trait: Jr. Asso. Phy. India (JAPI), Vol 49, Jan 2001. p. 97.

17) D. K. Patel. R. S. Panda. Serum Amylase in acute viral hepatitis. Diagnosis and prognostic significance:, Jr. Asso. Phy. India (JAPI)., Vol. 49. Jan 2001, p.129.

18) P. K. Mohanty, D. K. Patel, R. S. Panda. Unusual presentation of multiple myeloma: Report of three cases & review of literature: The Indian Practitioner August 2002, Vol. 56.8.p.535-538.

19) D. K. Patel, Panda A., Panda R. S. Study of cardiovascular dysfunction in sickle cell hemoglobinopathy in western Orissa.: Jr. Asso. Phy. India (JAPI), Vol. 50, Jan2002. p.756-57.

20) D. K. Patel & other. ULCIKIT in Acid peptic disorders - A post-marketing surveillance study. Performance of ULCIKIT 'N' dyspeptic / ulcer patients (POUNDUP) study group: participant’s doctors. The Indian Practitioner Vol. 55, No.3, March 2002. p. 157-163.

21) D. K. Patel, S. Patel, P. K. Mohanty, C D. Majhi, R. Nanda. Observation of various clinical status and complications in sickle cell trait in. Western Orissa: Jr. Asso. Phy. India (JAPI) 2003 Vol. 51 -p-1243.

22) D. K. Patel. Gene therapy: Update in Medicine, Vol. 1,2004, p. 7-13.

23) P. K. Mohanty, D. K. Patel, Majhi CD., R. Nanda, B. K. Rout, S. Guhathakurta. Aleukemic acute lymphoblastic leukemia in Adult presenting with reheumatic manifestations and osteolytic vertebral lesions: J Indian Rheumatol Assoc 2004: 12:150-152.

24) C. S. Sirka, T. Padhi, P.K.Mohanty, D. K. Patel, P. R. Padhi, C. R. Kar. Bullous systemic lupus erythematous: Response to dapsone in two patients: Indian Jr. of Dermatology, Venereology & Leprology. Vol 71, Issue 1, Jan-Feb, 2005, p.54-56.

25) D. K. Patel, P.K. Mohanty, S. R. Pattnaik, P. K. Padhi, S. Guhathakurta. Study of glycemic status & pancreatic pathology in sickle cell disease patients in Western Orissa: Jr. Asso. Phy. India (JAPI). Vol.53, Apr-2005-p.367-368.

26) B. N. Mohanty, B. Kuar, B.K.Das. R. Mohanty, S. Sarna. S.CMohanty. P.CMohapatra, S. N. Senapati. B. Parida. S.S. Mishra. D. K. Patel. S. K. Mishra. Distant Medical education through Telemedicine Network. Experience of Orissa Medical Colleges: "Abstract Book of lnternational Telemedicine Conference - INTELMEDINDIA 2005. p.106.

27) Patel D.K. Mohanty P.K., Panda R.S.: Linear scleroderma: An unusual presentation: J. Indian Rheumatol Assoc 2002: 10: 52-53.

28) DK Patel, PK Mohanty ,R Nanda, RS Panda Multiple Myelorna: Review of 21 cases with special reference to associated illnesses in a referral centre in Western Orissa.., Indian Practitioner May 2004, Vol. 57, No. 5, 285-292

29) PK Mohanty, DK Patel, CD Majhi, R Nanda, B Rout, S Guhathakurta, Aleukemic acute lymphoblastic leukemia in Adult presenting with reheumatic manifestations and osteolytic vertebral lesions: J Indian Rheumatol Assoc 2004: 12:150-152

30) S Mohanty, DK Patel, SS Pati, SK Mishra, Adjuvant therapy in cerebral malaria Indian Journal of Medical Research 2006, 124 (3), 245-60

31) PK Padhi, DKPatel, PK Mohanty, SC Sahoo, S Khan; Factors predicting morbidity & mortality in Idiopathic Dilated Cardiomyopathy - An in hospital survey. JAPI, 2006; vol-54; P 587-88.

32) DK Patel, PK Mohanty, PK Padhi, AK Dash; Clinical Profile of Tropical pyomyosities in a Tertiary care Hospital in western Orissa., Journal of Community Medicine, 2006, Vol. 2; No-2; P 82-84.

33) B.N. Mohanty, B.K. Das, B.K. Kuanr, R.M. Mohanty, C.R. Sarangi, A.C. Mohanty D.K. Patel, R. Mangual, D. Panigrahi, S.K. Mishra, Analysing four years of experience in use of Telemedicine in a state level tertiary care medical institution. Abstract book of Global Convention & Expo on Telemedicine & e-Health – 2006. p- 60.

34) Ramnath Mishra, Amit Agarwal, Vikash Agarwal, Able Lawrence, Bidut Das, D.K. Patel, Rajesh Basnet, Lily Kapoor, S.K. Mishra. Telemedicine as a tool of rheumatology teaching of Post graduate level., Abstract book of Global Convention & Expo on Telemedicine & e-Health – 2006. p.69

35) DK Patel, PK Mohanty, PK Padhi, RS Mashon, S Patel, SK Jena, Ellis- van Creveld syndrome with Sickle cell hemoglobinopathy and dyserythropoiesis: A rare combination, Journal of Community Medicine, Jan 2007, Vol. 3, No. 1, P 41-43.

36) Patel DK, Dash P, Mashon RS, Mohanty PK, Patel S, Das PK, Mohanty RC, Das UK. Molecular Diagnostic Techniques in Hemoglobinopathies & Infectious Diseases: Current Scenario in Western Orissa, Journal Community Medicine, Vol. 3, No. 2, July,2007, p. 51-58.

37) Patel DK, Patel S , Mashon RS, Dash P, Study of beta globin gene cluster haplotype and XmnI polymorphism in Sickle Cell Disease patients of Western Orissa (India) – A preliminary Report.” Abstract, International Conference on Emerging trends in Haematology and Immuno Hematology, Mumbai 31^st January 2007.

Guide to Post Graduate Thesis

Role of fetal hemoglobin to the different complications of sickle cell disease in India	Dr. N. Dora.
Level of serum Hemocystine level in Type – 2 DM	Dr. A. K. Behera
Study of sickle cell trait & its manifestation with special reference to vaso-occlusive crisis	Dr. Rajesh Nanda
Seroprevalence of hepatitis B virus and hepatitis C virus infection in sickle cell haemoglobinopathy	Dr. Prasanta Pradhan
Study of impaired glucose tolerance, diabetes mellitus and pancreatic pathology in sickle cell haemoglobinopathy	Dr. Sudeshna Guhathakurta
Evaluation of Iron status in Sickle Cell hemoglobinopathy in Western Orissa.	Dr. Biswaranjan Jena
Moniotoring the acute phase response with estimation of C- Reactive protein in Sickle Cell Disease with vaso occlusive crisis.	Dr. S. Singh
Study on prevalence of G6PD deficiency in Plasmodium falciparum malaria patient and correlate with morbidity & mortality.	Dr. D.D.Biswal
Trial of Hydroxyurea in treatment of Sickle Cell Disease in a tertiary care Hospital in Western Orissa PCR diagnosis & genotyping of Plasmodiuminfection in a tertiary care medical centre in Western Orissa	Dr. Lalit Pradhan Dr. Sanjeev

Guide for Indian council of Medical Research (ICMR) fellowship, Government of India
Name of Researcher: Mr. P.K.Banka Name of project:Study of incidence and severity of heptatoxic effects of first line anti tubercular drugs Year of study:2007 Funding agency:Indian council of Medical Research (ICMR), Govt. of India
Name of Researcher: Dr. Rajendra Name of project :Study of Anemia in pregnancy Year of study ;1993 Funding agency:Indian council of Medical Research (ICMR), Govt. of India
Guide to ongoing PhD degree programs
Beta globin gene cluster haplotype study of Indian population and its correlation with hematological parameters and clinical severity of Sickle Cell Disease.	Dr. R.S.Mashon
Study of Genetic Diversity of Sickle Cell Disease and its phenotypic expressions in association with other inherited globin gene disorders in Western Orissa, India.	Miss. P.Dash
Ongoing research activity
Trial of Hydroxyurea in treatment of Sickle Cell Disease & other compound heterozygous states (HbS-Thal, HbSE) in Western Orissa
To study the prevalence of various genetic disorders like alpha & beta Thalassemia, G6PD deficiency, Hemoglobin E disorder & malaria (P.falciparum, P.vivax) infection & their interaction with special reference to balanced polymorphism
Seroprevalence of Hepatitis B virus and Hepatitis C virus infection in sickle cell hemoglobinopathy.
To study the epidemiology, clinical features, hematological profile & haplotype analysis of Hemoglobin E disorders (HbE Trait, HbE Disease, HbE-Thalassemia, Hb SE) in Eastern India

Training

1. Attended work shop on “ The management of severe and complicated malaria” under the World bank Assisted Enhanced Malaria Control Project in collaboration with World Health Organization (WHO) at Ispat General Hospital, Rourkela, From 02.11.1998 to 06.11.1998.]

2. Attended training Programme on “Investigations and management f nutritional anemia” at National Institute of Nutrition (NIN) Hydrabad, India in the year 1999.

3. Adoption of guidelines for the “Management of severe falciparum malaria in small hospital & management of severe malaria with reference to acute renal failure” WHO workshop at IGH Rourkela 4^th – 6^th April 2001.

Guest Lecture

1. Snake bite – An update : Annual Conference of Association of Physicians of India, Orisa State Branch, held at M.K. C.G. Medical College, Berhampur on 5^th & 6^th Nov. 1994.

2. Recent advances in management of HCV Infection: Annual Conference of Association of Physicians of India, Orissa State Branch, held at V.S.S. Medical College, Burla on 22^nd & 23^rd Nov, 1997.

3. Epidemiology and management of HIV infection n Tuberculosis in India : Annual Conference of Association of Physicians of India, Orissa State Branch held at S.C.B. Medical College, Cuttack on 26^th & 27^th Feb. 2000.

4. Hope Trial. Current status is Indian context : CME in Diabetes by : Research society for the study of Diabetes in India (RSSDI) & IMA, held at Sambalpur, on 10^th Sept. 2000.

5. Use of Gene diversity in Medical Science: Refresher course on Biodiversity 12.09.2001 to 9.10.2001 conducted by Director UGC, Academic staff College, Sambalpur University.

6. Recent advances in diagnosis of Plasmodium falciparum malaria : Training workshop on malaria held at Jharsuguda, Orissa by N.A.M.A. on 21^st March 2002.

7. Recent advances in Diagnosis and treatment of hypertension in diabetes in India : CME on Hypertension & Coronary Artery Disease held at Railway Hospital, Sambalpur on 3^rd November 2002.

8. Sickle cell hemoglobinopathy & its interaction with falciparum malaria in Western Orissa : Govt. of Orissa Training Programme on Management of Severe falciparum malaria-Held at IGH Rourkela, Orissa, in March 2005.

Teaching Experience

1. Under Graduate Teaching & Examination: As lecturer 7 yrs. & as Asst. Prof. 9 years (Total 16 years).

2. Post Graduate Teaching: As Lecturer 7 yrs. & as Asst. Prof. 9 years (Total 16 years).

Research Project completed

1. Name of project : Trial of Shakhotaka in filariasis in Orissa

Period : 1985-87

Funding agency : Indian council of Medical Reseach (ICMR), Govt. of India

Status of Dr. D.K. Patel : Senior Research Fellow (SRF)